Rapid Reciprocal Changes in Rat Hepatic Glycolytic Enzyme and Fructose Diphosphatase Activities following Insulin and Glucagon Injection
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Rapid reciprocal changes in rat tissue enzyme activities following epinephrine injection.
Epinephrine infusion into the portal vein produced rapid changes in the activities of certain hepatic, epididymal fat, and skeletal muscle glycolytic enzymes and fructose diphosphatase in the rat. Epinephrine produced a rapid increase in hepatic, epididymal fat, and skeletal muscle fructose diphosphatase activity. In contrast, epinephrine produced a rapid decrease in hepatic phosphofructokinase...
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In an earlier report (1) we compared the responses of hepatic glycolytic enzyme activities of normal rats fed either glucose or fructose for 3 days. The enzymes studied were phosphoglucomutase, glucose 6-phosphatase, phosphoglucose isomerase, and the dehydrogenases of glucose B-phosphate and gluconate g-phosphate. When the diets containing free hexoses were substituted for the stock diet, the a...
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The effect of glucagon on the rate of gluconeogenesis from substrates not involving pathways of mitochondrial metabolism has been investigated in isolated rat liver cells. From estimation of the rates of glucose formation, glucose phosphorylation, fructose 6-phosphate phosphorylation, fructose 1,6diphosphate dephosphorylation, and lactate and pyruvate formation, it is concluded that glucagon st...
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A number of studies have brought to light the fact that substitution of fructose for glucose as the sole carbohydrate in a diet results in a profound change in the metabolic behavior of an animal. Thus, the ability of the liver of a glucose-fed, diabetic rat to convert acetate carbon to fatty acids is considerably impaired (l), but when the glucose of the animal’s diet is replaced by fructose, ...
متن کاملInhibition of bovine hepatic fructose-1,6-diphosphatase by substrate analogs.
Purified bovine hepatic fructose-1,6-diphosphatase, which exhibits maximal activity at neutral pH, is competitively inhibited by several analogs of its substrate, fructose 1,6-diphosphate. These include glucose 1,6-diphosphate (Ki = 9.4 X 10(-5) M), hexitol 1,6-diphosphate (Ki = 2.3 X 10(-4) M), and 2,5-anhydro-D-mannitol 1,6-diphosphate (Ki = 3.3 X 10(-8) M), and 2,5-anhydro-D-glucitol 1,6-dip...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)42096-6